These isoenzymes are reported to be singly or multi-expressed in a variety of normal tissues, including stomach, bowel, brain, heart, liver, pancreas, breast, kidney and skin at differing levels
Cancer Cell 2012;22:631-44
doi: 12
Determination of ligand-binding affinity (Kd) using transverse relaxation rate (R2) in the ligand-observed 1H NMR experiment and applications to fragment-based drug discovery
In one study, SNAC increased the absorption of a peptide (a short chain of amino acids) by nine-fold without affecting tight junctions
Additionally, many studies do not report changes in biomarkers of oxidative damage following AT treatment, making it difficult to assess whether any observed therapeutic benefit is actually attributable to the antioxidant activity