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ApoE is produced and secreted through a classical secretory pathway: Initially, it is synthesized in the endoplasmic reticulum (ER), after which it undergoes post-translational glycosylation and sialylation in the Golgi network

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296:2572-2581 [PubMed: 17101640] 100

J Neurosci 27(10):25962605 Nadjar A, Berton O, Guo S, Leneuve P, Dovero S, Diguet E, Tison F, Zhao B, Holzenberger M, Bezard E (2009) IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP