Ozempic belongs to the class of GLP-1 receptor agonists and works by mimicking the effects of a hormone called GLP-1
Composition: - Glutathione (reduced): a tripeptide consisting of glutamic acid, cysteine, and glycine
Sometimes they remain local
It was demonstrated that exenatide, a GLP-1R agonist, via activating the spinal dorsal horn GLP-1Rs, effectively blocked pain hypersensitivity and induced beta-endorphin release with subsequent activation of opioid receptors producing antinociception in pain hypersensitivity states (Gong et al
This broad receptor distribution underlies the pleiotropic research profile of GLP-1 from appetite and reward behaviour regulation in the central nervous system, to cardioprotective effects in cardiac tissue, to anti-inflammatory and immunomodulatory activity in immune cell models
[23] [24] However, translating these findings to human IBD requires caution, as animal models do not fully replicate the complexity of Crohn's disease