Vitamin B (pyridoxine), when chronically taken in gram quantities, is known to cause a sensory neuropathy, numbness and tingling in the extremities, but the amount of B in this formula is far below such neurotoxic levels
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Apparently the underlying thought is that it is necessary to keep the value between the (upper and lower) reference values
For a 5 mg semaglutide vial, 0.5-1 mL of bacteriostatic water creates a concentrated solution appropriate for the tiny weekly doses
Safety and Side Effects: Most side effects are mild and temporary
A 2008 study published in the Journal of Medicinal Chemistry demonstrated metabolic effects in rodent models at 50mg/kg, which led early researchers to extrapolate human-equivalent doses between 50100mg daily