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Discussion Australia has undergone a recent comprehensive review of its regulatory system for therapeutic products
D.WongJ.PahlM.PicenoY
The result is that, rather than neutralising free radicals, your product will be generating them
However, small-molecule 3 was quite lipophilic (logD 7.4 = 5.7), resulting in high metabolic intrinsic clearance in human liver microsomes (HLM) (CL int = 130 mL/min/kg, Table S4), which would likely lead to a short pharmacokinetic half-life (t 1/2 ) and the requirement for an unacceptably high daily dose in humans
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