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The 12 mg row is included for completeness because the Phase 2 trial escalated through 1 mg, 2 mg, 4 mg, 8 mg and 12 mg arms, with the 12 mg cohort reaching approximately 24.2% mean weight loss at 48 weeks at the cost of a heavier nausea and constipation burden [2][5]

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Mayo Clinic clearly states that prescription weight-loss drugs should be combined with lifestyle changes

How have costs associated with obesity changed over time

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Variants in GLP1R (the GLP-1 receptor gene that every GLP-1 compound targets), FTO (the fat-mass and obesity-associated gene), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (a transcription factor tied to glucose homeostasis) describe the terrain a clinician prescribes into