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However, these proteins were in circulation for only a short time, limited to 1-2 minutes, due to their degradation by the enzyme dipeptidyl peptidase-4 (DPP-4), which raised questions regarding use of GLP-1s as pharmaceutical treatments [9]

All GLP-1 receptor agonists slow gastric emptying through the same biological mechanism, so both semaglutide and tirzepatide produce similar digestive side effects during the adjustment phase