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They interact mainly with receptors involved in hormone release and appetite-related signaling

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Most human trials show modest average changes

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Situations requiring careful assessment include a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2), diabetic retinopathy (particularly proliferative retinopathy, where rapid glucose reduction may temporarily worsen the condition), history of pancreatitis, gallbladder disease, and renal impairment

This fueled an exponential growth in interest among the public, but not everyone qualifies for GLP-1s through their insurance or can afford them, even if they do