The Sustainability Question Research consistently shows weight regain is common after GLP-1 medication discontinuation
doi:10.1002/lary.32389)
Summary GLP-1RA-mediated weight loss is achieved through multiple pathways including effects on the central nervous system such as reduced appetite, energy intake, and hunger, increased feelings of satiety, and altered food preferences
Some patients lose even more, while others lose slightly lessindividual results vary based on starting weight, adherence, lifestyle factors, and metabolism
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Furthermore, the addition of GLP1Ra to SGLT2i showed an advantage in the decrease in BW