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Challenges include stringent regulatory requirements across different markets, cost pressures affecting procurement decisions, and the need for consistent supply chain reliability

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The STEP trials showed semaglutide's cardiovascular and metabolic benefits across obese populations, but many smaller studies and real-world data support its use in insulin-resistant or prediabetic individuals at lower BMI levels

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Some of these beneficial effects are due to weight loss, but emerging data suggest that GLP-1 mimetics may have direct effects on the kidneys and vasculature