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This argues that in the context of CNS disorders, that shaped glial responses during evolution, such as responses to microbial infections and traumatic injury, astrocyte reactivity exerts essential beneficial functions

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Infectious agents Extensive efforts have been made, with limited success, to establish an infectious agent as the cause of IC

Understanding how these agents work independently is essential before considering their combined use, as their distinct mechanisms may theoretically interact in ways that are not yet fully characterized in clinical literature

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