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The relative contributions of signals from regions within the peripheral nervous system or CNS that transduce the anorectic effects of GLP-1R agonists are not known precisely

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In the study by Goldstone et al., fasting leptin levels were significantly higher in subjects with PWS ( n = 42, aged 7 months5 years) compared to age-, sex- and BMI-matched controls ( n = 9) , without any significant relationship with age, BMI and eating behaviour [45]

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In D-galactose-induced aging rats, L-theanine could protect the liver not only by reducing the levels of pro-inflammatory factors, such as IL-1, TNF-, and IL-6 but also by efficiently reducing the production of edema and vacuole induced by D-galactose (88)