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have designed and synthesized highly constrained GLP-1 analogs containing two or three lactam bridges between Glu i and Lys i +4 that were placed simultaneously to stabilize the both helical structures in the N- and C-terminal regions

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Therefore, induced levels of GLP-1 during an oral glucose or meal test have been consistently reported after RYGB (Yi et al., 2008), BPD (Jin and Weng, 2016), and SG (Moellmann et al., 2018) (Figure 4)