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Semax is formally an analog of the ACTH(4-10) fragment, the active core Met-Glu-His-Phe capped with a stabilizing Pro-Gly-Pro tail that keeps it from being chewed up too fast, and it is stripped of the parent hormones effects on the adrenal glands, so it acts on the brain without the stress-hormone baggage

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The AUA names this the single most effective stone-prevention step, cutting recurrence by more than half.[1] The easiest daily gauge is color: aim for pale straw, not dark yellow

Hammersley, D

This could partially account for the lower relative fold induction observed in these cells