By now Holst had joined them as a consultant (Molteni, Chen)
2024;326(3):E268-E276
Open 2 , e1915219 (2019)
Starting a new exercise program simultaneously with a new medication is challenging
However, as use becomes more common in clinical practice, endocrinologists and primary care providers must balance glycemic outcomes, weight loss expectations, safety considerations, and realworld access
Insulin resistance and chronic hyperglycemia cause a cascade of pathological events in the brain, including neuroinflammation, impaired neurotransmitter systems and energy metabolism, oxidative stress, and vascular pathologies that ultimately lead to neurodegeneration, loss of synaptic plasticity, brain aging, cognitive impairment, and dementia