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A direct detrimental incretin effect on the central nervous system could also be hypothesized and susceptible people receiving GLP-1 RAs may, in some circumstances, experience a worsening of hedonic tone predisposing psychopathology and/or self-harm ideation and/or other aspects of suicidality

Unlike anabolic steroids such as Trenbolone, which act through androgenic pathways, MOTS-c delivers performance benefits via energy regulation rather than muscle-binding hormones

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This is especially important for tissues with poor blood supply, like tendons and ligaments

23,36,43 It has also been proposed that increased scrotal fat may impair sperm development through thermal effects