The gut releases GLP-1 after eating. It triggers the pancreas to release insulin, slows gastric emptying, and acts on the hypothalamus to control hunger signals. In obese people, GLP-1 signalling tends to be blunted they feel less full after eating than lean people do. Semaglutide, the synthetic GLP-1 analogue, has a half-life of about a week, which enables convenient weekly dosing. 02 MECHANISM Semaglutide works on three key areas the brain to control appetite, the stomach to slow digestion, and the pancreas to regulate blood sugar
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[Published online February 12, 2026] Almadfaa RO
