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Although there is no definitive evidence regarding the causal relationship between the use of GLP-1 RAs in humans and the development of psychiatric AEs, the fact that psychiatric AEs have occurred after the use of GLP-1 RAs suggests that these reports warrant increased clinical attention, early detection, and intervention

The first outcome of interest (as reported in the original analysis) is weight

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10.1053/j.gastro.2011.01.046 18 Gutierrez-AguilarR.WoodsS

Researchers subsequently determined that MT-IIs effect on sexual arousal is mediated via interaction with the MC-3 and MC-4 receptors in the central nervous system, which function independently of the MC-1 receptors in melanocytes responsible for tanning [20]