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doi: 10.3389/fcell.2021.733908 Received 06 July 2021 Accepted 25 October 2021 Published 11 November 2021 Volume 9 - 2021 Edited by Yi Zhang, First Affiliated Hospital of Zhengzhou University, China Reviewed by Qianyi He, First Affiliated Hospital of Zhengzhou University, China Nao Yan, Wuhan University, China Updates Copyright 2021 Luo, Su, Gong, Liang, Huang, Chen, Wang and Tian

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5H, I), while overexpression of a codon-optimized L2HGDH (L2HGDH OPT ), which is resistant to the designed sgRNA, reverses this effect (Fig