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Treatment is usually limited to up to 2 years

Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5 24 million UK adults

While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition

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Overall, our data suggest that females show reduced glucose-lowering benefit from GLP1-M treatment Table 4)