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Administration of free-form superoxide dismutase has several disadvantages, the most important of which is the low accumulation of superoxide dismutase in inflamed areas due to its reduced half-life in the bloodstream and its rapid excretion through the kidneys

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Over the decades, the EAE model, focused primarily on T cells, has been the model for MS pathogenesis and treatment studies (Preiningerova et al., 2022)

Biomaterials 83 , 156168 (2016)

Legro RS, Barnhart HX, Schlaff WD, et al

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