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A study by Gwin and colleagues found that five days of a 30% caloric deficit required a three-fold increase in EAA intake to maintain a positive whole-body protein balance. When those elevated EAA requirements are not met through diet, the body breaks down muscle protein to supply the necessary amino acidsan outcome that cannot be fully reversed until EAA intake catches up

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3 Incretin-based therapies not only address these conditions but have also gained popularity recently due to their powerful effects on blood sugar and weight management, 4,5 as well as their enhancement of systemic and liver insulin action

Source: NEJM 2023 Safety profile: The most common adverse events were gastrointestinal (nausea 58%, diarrhea 39%, vomiting 32% in the 12 mg group)

HbA1c variability as an independent correlate of nephropathy, but not retinopathy, in patients with type 2 diabetes: the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicenter study

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