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There is no clinical evidence that tapering provides any benefit before switching

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In line with this notion, pharmacologic or genetic suppression of GLP-1R in the lateral septum attenuates the ability of cocaine to activate the mesolimbic dopamine system, as assessed by hyperactivity, reward in the CPP test, and dopamine enhancement in the NAc (Reddy et al., 2016)

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In fact, many of these patients tend to regain weight and sometimes put on even more over the long term