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Eli Lilly is one of the two companies that dominate the GLP-1 receptor agonist landscape, and understanding its portfolio helps make sense of the broader competitive picture, along with the genetic variables that sit upstream of every compound regardless of manufacturer

The LEADER trial showed semaglutide reduced cardiovascular death by 26% in patients with established heart disease regardless of baseline weight

The trial was powered according to the total population

In T2DM, a classic metabolic disorder characterized by such dysbiosis, a reduction in the abundance of Bacteroides and Bifidobacterium, alongside an increase in Fusobacterium , is commonly observed (Ma et al., 2019

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