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Dosing and Administration: What to Expect Zepbound Dosing Schedule Zepbound is administered as a once-weekly subcutaneous injection: Weeks 1-4: 2.5 mg once weekly Weeks 5-8: 5 mg once weekly Weeks 9+: Increase by 2.5 mg every 4 weeks as tolerated Maintenance Dose: 5 mg, 10 mg, or 15 mg once weekly Most patients in clinical trials (89.3%) reached the maximum 15 mg dose, demonstrating good tolerability with gradual escalation