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By far, it has shown the highest average weight loss results in a clinical trial with 22.5% average weight loss at 72 weeks (SURMOUNT-1, NEJM 2022)
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academic.oup.com/jes/article/9/ Gut hormones like ghrelin ( hunger) & GLP-1/PYY ( hunger) signal to the hypothalamus' arcuate nucleus
The serum samples without APP treatment served as controls, while serum samples in the treatment group received APP treatment for the indicated durations
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