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Landmark studies such as LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide) have shown significant reductions in major adverse cardiovascular events (MACE), including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke, in patients with type 2 diabetes and established cardiovascular disease or multiple risk factors

10.1016/j.freeradbiomed.2009.08.021 30

Diabetes 68 , 17091716 (2019)

Stevens, H., de la Paz, M., Cooper, B

In addition, there was a significant nonlinear relationship between dose (2 g/day) and changes in insulin, as well as a significant linear relationship between the duration (weeks) (coefficients = 16.45, p = 0.004) of intervention and changes in HbA1C