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MOTS-c prevents weight gain and reduces adiposity in ovariectomized mice (used to mimic menopause) by reducing blood lipids and hepatic triacylglycerol levels, while also enhancing lipolysis [44]

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doi: 10.1097/00006676-199007000-00018 28 Hopsu-HavuVKGlennerGG

The Cambridge paper specifically flagged this as a critical gap in the research that future trials need to address, because no studies have yet systematically tracked body composition changes after discontinuation