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During periods of rapid weight loss, the body interprets the change as a mild stressor

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However, because GLP-1 treatments typically begin at a low titration dose to allow the body to adjust and minimize side effects, the appetite suppression may feel mild during the first week

doi: 10.3892/mmr.2014.2555 78 ZhouT.ZhangM.ZhaoL.LiA.QinX

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Indeed, the experience of several randomized control trials has been included in the most recent guidelines ( In patients with T2DM, the treatment with SGLT2-i has been associated with a reduction in hospitalization for heart failure and cardiovascular deaths, regardless of pre-existing cardiovascular disease ( Several studies ( This heterogeneity in CV benefits across the trials, also among studies in which drugs of the same class have been used, could be explained by different study designs (i.e