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J., Vilsboll, T

Studies showed increased risk of thyroid tumors, though this hasnt been confirmed in humans

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The most frequently reported symptoms included: Nausea (the most common, with rates varying by dose readers should refer to the published trial data and supplementary tables for dose-specific figures) Vomiting Diarrhoea Constipation Upper abdominal pain or discomfort Decreased appetite These effects are largely attributable to the drug's action on GLP-1 receptors in the gastrointestinal tract, which slow gastric motility and alter gut hormone signalling

( Epub 20180402 )

This is one reason scientists continue developing new molecules like UBT251 even after compounds such as Retatrutide enter the spotlight