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It originated as part of Lilly's program to extend the dual-agonist concept proven by tirzepatide into a triple-agonist class, and it is the first such molecule to advance into Phase 3 in any indication [1][3][4]

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Diarrhea was reported in 34.7% and 33.1%, constipation in 21.8% and 25.0%, and vomiting in 20.4% and 20.9%, respectively

This is consistent with NICE guidance (CG189) on multicomponent weight management interventions, including those delivered through Tier 3 specialist weight management services