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Structurally its a pentapeptide Aib-His-D-2Nal-D-Phe-Lys-NH and those non-standard residues at positions 1 and 3 (alpha-aminoisobutyric acid and D-beta-naphthylalanine) turn out to be doing most of the pharmacological work

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It is prominently expressed in the ileum (a part of the small intestine) and has been linked to intestinal inflammation (Liu et al., 2023)