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Similar lean-mass proportion is not the same as builds muscle or preserves all muscle automatically. Across obesity treatment generally, lean body mass loss still occurs with weight reduction, including with GLP-1based therapies, and newer expert commentary continues to emphasize muscle preservation as a major clinical priority

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GLP-1 medications have transformed the weight loss landscape GLP-1 medications such as semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound) have transformed the weight loss landscape