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it is often a central part of the hormonal imbalance

10.2337/dc14-2441 92 IqbalN.ParkerA.FrederichR.DonovanM.HirshbergB

The hormonal system is off-balance low thyroid, cortisol changes, testosterone changes, etc

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A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects

You can have all the testosterone in the world floating in your system, but if you dont have the androgen receptors to bind toyour screwed