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Telomere shortening is another important age-related process, accelerated by ROS

However, levels drop when oxidative stress shoots up, such as during aging, or when you are exposed to toxins, illness, or injury

Int Immunol (2014) 26:23342

The TME encompasses a spectrum of components, including the extracellular matrix (ECM), fibroblasts, immune cells, vasculature, mesothelial cells, and their metabolites[33]