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Srenson's thinking was coloured by the fact that a previous drug, Redux, approved in 1996 by the FDA for weight loss and launched with great fanfare, had to be withdrawn a year later after it was found to cause major heart attacks and to be largely ineffective

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Accessed February 2026

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However, meta-analyses of clinical trials has revealed a reduction of 10% in the incidence of both new and recurrent myocardial infarctions with GLP-1RAs [8]