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Excessive TDP-43 can also induce mitochondrial DNA leakage into the cytosol, which activates NF-B and type I interferon pathways that drive neuroinflammatory responses (Yu et al., 2020)

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[DOI] [PubMed] [Google Scholar] 292.Helsmoortel C, Vulto-van Silfhout AT, Coe BP, Vandeweyer G, Rooms L, van den Ende J, et al

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