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AIFM1 mutations have been associated with wide spectrum of clinical phenotypes with X-linked recessive inheritance including a severe, early-onset mitochondrial encephalomyopathy with combined oxidative phosphorylation deficiency [155] , prenatal ventriculomegaly [156] , the Cowchock syndrome, an X-linked Charcot-Marie-Tooth disease (CMTX4) with axonal sensorimotor neuropathy, deafness and cognitive impairment [157] , auditory neuropathy spectrum disorder [158] , spondyloepimetaphyseal dysplasia with mental retardation [159] , and, more recently, cerebellar ataxia partially responsive to riboflavin [160]

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Raffoul W, Far MS, Cayeux MC, Berger MM

Users of oxidative-stress-inducing medications (e.g., frequent acetaminophen) may require additional antioxidant support, though supplementation should not replace medical liver management

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It helps neutralize harmful free radicals and reduce oxidative stress, which is linked to various chronic diseases and the aging process