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PH fibroblasts drive pro-inflammatory phenotypes and glycolysis in macrophages via small extracellular vesicles (sEVs) containing complement C3 (Kumar et al., 2021)

Genetic CI dysfunction in several tissues remodels the global transcriptome and alters cell state through retrograde signalling 24,25

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The exact cause of PTLDS is not well understood, but it may involve a combination of factors such as an ongoing immune response, tissue damage from the initial infection, and possibly the presence of co-infections

If irritation occurs, reduce application frequency to 2-3 times per week or discontinue use

Choose the Right Formulation Some delivery methods are more effective than others