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For example, Ace2 -knockout mice have been found to be more susceptible than wild-type mice to high-fat diet-induced pancreatic -cell dysfunction 56

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The highest severity of intestinal lesions was noted in the AA group, followed in descending order by rutin nanoformulation at doses of 100, 150, and 200 mg/kg, respectively (Figure 8)

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Naini AE, Moradi M, Mortazavi M, Amini Harandi A, Hadizadeh M, Shirani F, et al