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DOI: 10.1038/s41591-022-02026-4

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Notably, the identification of thalidomide and its analogs as CRBN ligands vastly expanded the E3 ligase toolbox [48], spurring a wave of VHL- and CRBN-based PROTACs such as ARV-825 and DBET1 that achieved potent degradation of BRD4 and AR in cellular models [49, 50]

No se han observado evidencias de elevacin significativa del cortisol, alteraciones de la prolactina ni efectos hepticos adversos en los datos de investigacin disponibles

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