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Under stress conditions, the GSTM1-1ASK1 complex dissociates, causing the oligomerization of GSTM1-1 and the activation of ASK1, which subsequently activates JNK and P38 pathways, leading to apoptosis [66]

These counter-regulatory changes induce hyperphagia and a hypometabolic state, which result in tachyphylaxis to anorectic medications and favor weight regain

Pezzulo, A

also reported to influence appetite and libido in some contexts

The neuroprotective effects come through multiple pathways: inhibition of nitric oxide synthesis under ischemic conditions, antioxidant activity, protection against glutamate neurotoxicity, and mitochondrial stabilization under calcium dysregulation

Dimethyl sulfoxide (DMSO), a nonselective inhibitor of NLRP3, exerts its inhibitory function by disrupting the interaction between NLRP3 and thioredoxininteracting protein (TXNIP)