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GLP-1RAs were originally developed for glycemic control in type 2 diabetes, with subsequent large-scale trials confirming cardiovascular benefits in high-risk populations

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doi:10.3390/metabo10070285

When it comes to treatment goals, the medications fall into two main categories: those targeting type 2 diabetes (Ozempic, Rybelsus, Mounjaro, Victoza, and Trulicity) and those approved for weight management (Wegovy, Zepbound, and Saxenda)

The evidence base remains limited, with most studies being small, short-term, and often focused on liraglutide rather than semaglutide

The fibrotic remodeling can progress from mild (stage F1) to cirrhosis (stage F4) if left unchecked 2