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People with the MTHFR C677T homozygous (AA genotype) have been shown to benefit most from folate to lower homocysteine

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Furthermore, supplementation with riboflavin results in marked lowering of homocysteine concentrations specifically in individuals with the variant MTHFR 677TT genotype (15)

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Cautions and Risks This essential vitamin is water soluble and generally considered safe at doses up to 2,000 mg a day, according to the Mayo Clinic