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Compound 2 forms predominantly hydrophobic interactions with the adjacent residues in TM6

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Microglia-specific metabolic changes in neurodegeneration

In addition, GLP-1RAs carry a black box warning for medullary thyroid carcinoma (MTC) and are contraindicated in patients with a personal or family history of MTC or multiple endocrine neoplasia syndrome type 2 (MEN2)

Our results are conducive to further understanding the regulatory effect of GLP-1R on glucose metabolism in the central nervous system, and provide a theoretical basis for the future development of GLP-1R-related drugs