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The collagen synthesis mechanisms involve MAPK/ERK pathway activation, which upregulates collagen gene expression at the genetic level

3,4 Due to the overlap in chronic inflammatory pathophysiology, GLP-1 RAs may serve as a potential therapeutic candidate for the management of these skin disorders, particularly those co-occurring with metabolic dysfunction

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In contrast, the 2024 ACC/AHA guideline incorporated data from randomized controlled trials and meta-analyses