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10.1007/s00125-016-3935-2 [DOI] [PMC free article] [PubMed] [Google Scholar] Jastreboff A

"Smaller players will likely need to demonstrate either superior tolerability, novel indication-specific efficacy, meaningfully different dosing convenience, or combination strategies that address limitations of current agents, particularly muscle loss, rather than simply competing on weight-loss magnitude alone," says Nadolsky

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This study aims to address these gaps by rethinking Williams circular development framework, structured around three interrelated goals: resource looping, ecological regeneration, and adaptation actions