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Measures were taken to minimise pain and discomfort of the animals in accordance with the Directive 40/2013 (II.14): On animal experiments issued by the Government of Hungary, and the Directive 2010/63/EU On the protection of animals used for scientific purposes issued by the European Parliament and the European Council

GLP-1 agonists target the GLP-1 receptor only

GLP-1 and glucagon promote weight loss through distinct mechanisms of action GLP-1 is believed to act predominantly in the hypothalamus to induce satiety, whereas the weight-lowering effects of glucagon are mostly driven by its lipolytic and thermogenic effects in liver and the adipose tissue [56]

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However, lawsuits say these warnings were not and continue to be inadequate to properly inform patients of potential side effects