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10-14 The Diabetes Control and Complications Trial demonstrated a relationship between improved blood glucose control and increased risk of early worsening of DR, as well as between long-term risk reduction of DR with sustained blood glucose improvement

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They carry a boxed warning for people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

Other reported side effects include: Nausea and vomiting Flushing and increased heart rate Darkened freckles and moles Unintended weight loss Melanotan vs