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Common Injection Pain Concerns and What the Evidence Shows Some patients report brief stinging at the injection site, but clinical data indicates this occurs in fewer than 10% of GLP-1 users and is usually mild and temporary

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Participants receiving semaglutide demonstrated lower post-treatment drinking and craving scores, and while changes in overall drinking days were not observed, there was a progressive decline in heavy drinking days within the semaglutide group (Hendershot et al., 2025)